Prof. Dr. Gunnar W. Klau

We develop algorithmic models and methods to better understand cellular processes based on molecular data. Current applications include genome analysis, models for vaccine development and AI-assisted systems for decision support.

The work is highly interdisciplinary and is characterized by cooperations with experimental  partners.

1. Serra Mari R, Schrinner S, Finkers R, Ziegler FMR, Arens P, Schmidt MH, Usadel B, Klau GW, Marschall T (2024) Haplotype-resolved assembly of a tetraploid potato genome using long reads and low-depth offspring data. Genome Biol 25(1):26. doi: 10.1186/s13059-023-03160-z.
2. Tran NK, Kühle LC, Klau GW (2024) A critical review of multi-output support vector regression. Pattern Recog Lett 178:69-75. doi: 10.1016/j.patrec.2023.12.007.
3. Schulte SC, Dilthey AT, Klau GW (2023) HOGVAX: Exploiting epitope overlaps to maximize population coverage in vaccine design with application to SARS-CoV-2. Cell Systems 14(12):1122-1130.e1123. doi: 10.1016/j.cels.2023.11.001.
4. van Mantgem ES, Hillebrand J, Rose L, Klau GW (2023) Coco: conservation design for optimal ecological connectivity. Frontiers in Ecology and Evolution 11. doi: 10.3389/fevo.2023.1149571.
5. McGuinness KN, Klau GW, Morrison SM, Moore EK, Seipp J, Falkowski PG, Nanda V (2022) Evaluating Mineral Lattices as Evolutionary Proxies for Metalloprotein Evolution. Origins of Life and Evolution of Biospheres 52(4):263-275. doi: 10.1007/s11084-022-09630-x.
6. Schrinner S, Serra Mari R, Finkers R, Arens P, Usadel B, Marschall T, Klau GW (2022) Genetic polyploid phasing from low-depth progeny samples. iScience 25(6):104461. doi: 10.1016/j.isci.2022.104461.
7. Schrinner SD, Mari RS, Ebler J, Rautiainen M, Seillier L, Reimer JJ, Usadel B, Marschall T, Klau GW (2020) Haplotype threading: accurate polyploid phasing from long reads. Genome Biol 21(1):252. doi: 10.1186/s13059-020-02158-1.