Dr. Tobias Jores
Research Focus
Our research focuses on understanding gene regulatory logic in plants. Using high-throughput assays, we characterize the condition- and species-specific activity of hundreds of thousands of plant cis-regulatory elements. Using this data, we are developing deep learning models that predict the activity of novel sequences and enable the design of synthetic cis-regulatory elements. In parallel, we are developing a toolkit for transgene-free genome editing of cis-regulatory elements.
The five most important publications
- Jores T, Tonnies J, Mueth N, Romanowski A, Fields S, Cuperus JT, and Queitsch C (2023) Cooperativity and additivity in plant enhancers. bioRxiv, doi.org/10.1101/2023.11.21.568158.
- Jores T, Hamm M, Cuperus JT, and Queitsch C (2023) Frontiers and techniques in plant gene regulation. Current Opinion in Plant Biology 75, 102403.
- Gorjifard S, Jores T, Tonnies J, Mueth NA, Bubb K, Wrightsman T, Buckler ES, Fields S, Cuperus JT, and Queitsch C (2023) Features that Govern Terminator Strength in Plants. bioRxiv, doi.org/10.1101/2023.06.16.545379.
- Jores T, Tonnies J, Wrightsman T, Buckler ES, Cuperus JT, Fields S and Queitsch C (2021) Synthetic promoter designs enabled by a comprehensive analysis of plant core promoters. Nature Plants 7, 842–855.
- Jores T, Tonnies J, Dorrity MW, Cuperus JT, Fields S, and Queitsch C (2020) Identification of Plant Enhancers and Their Constituent Elements by STARR-seq in Tobacco Leaves. The Plant Cell 32, 2120–2131.
Dr. Tobias Jores
Institute of Synthetic Biology
Heinrich Heine University Düsseldorf
https://www.synthetic-biology.hhu.de/en/research/dr-jores-group