How cells repair their power plants
Scientists from the University of Cologne and the University Clinics from Heinrich-Heine University Düsseldorf, have uncovered a groundbreaking mechanism used by cells to protect and repair mitochondria.
The study, led by Dr. David Pla-Martín, revealed that when mitochondrial DNA is damaged, cells activate a specialized recycling system. To verify and extend their findings, Dr. Pla-Martín collaborated with CEPLAS academic expert in Imaging Parisa Kakanj, who specializes in research using fruit flies (Drosophila), a widely-used model organism. Parisa Kakanj adapted this discovery to fruit flies, demonstrating that enhancing the activity of the retromer complex significantly speeds up the removal of damaged mitochondrial DNA, greatly improving mitochondrial function.
This breakthrough provides important insights into the natural defenses our cells use against aging and mitochondrial diseases.