Prof. Dr. Guido Grossmann

Research focus

Through interactions, biological systems can develop functionalities that go beyond the mere sum of their parts. We study biological interactions on the level of proteins as well as organisms with a focus on their establishment and emerging properties. From the formation of signaling clusters of membrane proteins regulating cellular growth and morphology in plant cells, to the interaction between roots and soil microbes shaping diverse microenvironments, our research aims to unveil the intricacies of nature's collaborations.

We develop approaches for advanced automated and robotics-assisted imaging, specimen handling and imaging data analysis. Our lab has pioneered microfluidic perfusion systems for plants (RootChip) that enable quantitative microscopy of metabolite dynamics and signaling responses to changing environmental conditions. Our soil-inspired, structured cultivation devices facilitate live high-resolution imaging of root colonization by microbes.

Most important publications

  1. VanBuren R, Wai CM, Giarola V, Zupunski M, Pardo J, Kalinowski M, Grossmann G, Bartels D (2023) Core cellular and tissue-specific mechanisms enable desiccation tolerance in Craterostigma. Plant J 114(2):231-245. doi: 10.1111/tpj.16165.
  2. Liu S, Strauss S, Adibi M, Mosca G, Yoshida S, Dello Ioio R, Runions A, Andersen TG, Grossmann G, Huijser P, Smith RS, Tsiantis M (2022) Cytokinin promotes growth cessation in the Arabidopsis root. Curr Biol 32(9):1974-1985 e1973. doi: 10.1016/j.cub.2022.03.019.
  3. Roszak P, Heo JO, Blob B, Toyokura K, Sugiyama Y, de Luis Balaguer MA, Lau WWY, Hamey F, Cirrone J, Madej E, Bouatta AM, Wang X, Guichard M, Ursache R, Tavares H, Verstaen K, Wendrich J, Melnyk CW, Oda Y, Shasha D, Ahnert SE, Saeys Y, De Rybel B, Heidstra R, Scheres B, Grossmann G, Mahonen AP, Denninger P, Gottgens B, Sozzani R, Birnbaum KD, Helariutta Y (2021) Cell-by-cell dissection of phloem development links a maturation gradient to cell specialization. Science 374(6575):eaba5531. doi: 10.1126/science.aba5531.
  4. Denninger P, Reichelt A, Schmidt VAF, Mehlhorn DG, Asseck LY, Stanley CE, Keinath NF, Evers JF, Grefen C, Grossmann G (2019) Distinct RopGEFs Successively Drive Polarization and Outgrowth of Root Hairs. Curr Biol 29(11):1854-1865 e1855. doi: 10.1016/j.cub.2019.04.059.
  5. Brost C, Studtrucker T, Reimann R, Denninger P, Czekalla J, Krebs M, Fabry B, Schumacher K, Grossmann G, Dietrich P (2019) Multiple cyclic nucleotide-gated channels coordinate calcium oscillations and polar growth of root hairs. Plant J 99(5):910-923. doi: 10.1111/tpj.14371.
  6. Stanley CE, Shrivastava J, Brugman R, Heinzelmann E, van Swaay D, Grossmann G (2018) Dual-flow-RootChip reveals local adaptations of roots towards environmental asymmetry at the physiological and genetic levels. New Phytol 217(3):1357-1369. doi: 10.1111/nph.14887.
  7. Xing S, Mehlhorn DG, Wallmeroth N, Asseck LY, Kar R, Voss A, Denninger P, Schmidt VA, Schwarzländer M, Stierhof YD, Grossmann G, Grefen C (2017) Loss of GET pathway orthologs in Arabidopsis thaliana causes root hair growth defects and affects SNARE abundance. Proc Natl Acad Sci U S A 114(8):E1544-E1553. doi: 10.1073/pnas.1619525114.
  8. Keinath NF, Waadt R, Brugman R, Schroeder JI, Grossmann G, Schumacher K, Krebs M (2015) Live Cell Imaging with R-GECO1 Sheds Light on flg22- and Chitin-Induced Transient [Ca(2+)]cyt Patterns in Arabidopsis. Mol Plant 8(8):1188-1200. doi: 10.1016/j.molp.2015.05.006.
  9. Denninger P, Bleckmann A, Lausser A, Vogler F, Ott T, Ehrhardt DW, Frommer WB, Sprunck S, Dresselhaus T, Grossmann G (2014) Male-female communication triggers calcium signatures during fertilization in Arabidopsis. Nat Commun 5:4645. doi: 10.1038/ncomms5645.
  10. Grossmann G, Guo WJ, Ehrhardt DW, Frommer WB, Sit RV, Quake SR, Meier M (2011) The RootChip: an integrated microfluidic chip for plant science. Plant Cell 23(12):4234-4240. doi: 10.1105/tpc.111.092577.



Prof. Dr. Guido Grossmann

+49 0211 81 14746

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Institute of Cell and Interaction Biology
Heinrich Heine University Düsseldorf