Prof. Dr. Ilka Maria Axmann
Research focus
Smart, automated and dynamic control of synthetic metabolic pathways in microorganisms is aimed using synthetic RNA-devices and RNA-based metabolite-sensors. Particular focus is placed on the engineering of cyanobacteria as a future host for sustainable biotechnology.
The ten most important publications
- Guerreiro AC, Penning R, Raaijmakers LM, Axman IM, Heck AJ, Altelaar AF (2016) Monitoring light/dark association dynamics of multi-protein complexes in cyanobacteria using size exclusion chromatography-based proteomics. J Proteomics 142:33-44.
- Amos M, Axmann IM, Blüthgen N, de la Cruz F, Jaramillo A, Rodriguez-Paton A, Simmel F (2015) Bacterial computing with engineered populations. Philos Trans A Math Phys Eng Sci 373(2046).
- Snijder J, Burnley RJ, Wiegard A, Melquiond AS, Bonvin AM, Axmann IM, Heck AJ (2014) Insight into cyanobacterial circadian timing from structural details of the KaiB-KaiC interaction. Proc Natl Acad Sci U S A 111(4):1379-1384.
- Beck C, Hertel S, Rediger A, Lehmann R, Wiegard A, Kölsch A, Heilmann B, Georg J, Hess WR, Axmann IM (2014) Daily expression pattern of protein-encoding genes and small noncoding RNAs in synechocystis sp. strain PCC 6803. Appl Environ Microbiol 80(17):5195-5206.
- Lehmann R, Machné R, Georg J, Benary M, Axmann I, Steuer R (2013) How cyanobacteria pose new problems to old methods: challenges in microarray time series analysis. BMC Bioinformatics 14:133.
- Hertel S, Brettschneider C, Axmann IM (2013) Revealing a two-loop transcriptional feedback mechanism in the cyanobacterial circadian clock. PLoS Comput Biol 9(3):e1002966.
- Beck C, Knoop H, Axmann IM, Steuer R (2012) The diversity of cyanobacterial metabolism: genome analysis of multiple phototrophic microorganisms. BMC genomics 13:56.
- Brettschneider C, Rose RJ, Hertel S, Axmann IM, Heck AJ, Kollmann M (2010) A sequestration feedback determines dynamics and temperature entrainment of the KaiABC circadian clock. Mol Syst Biol 6:389.
- Axmann IM, Dühring U, Seeliger L, Arnold A, Vanselow JT, Kramer A, Wilde A (2009) Biochemical evidence for a timing mechanism in prochlorococcus. J Bacteriol 191(17):5342-5347.
- Lindell D, Jaffe JD, Coleman ML, Futschik ME, Axmann IM, Rector T, Kettler G, Sullivan MB, Steen R, Hess WR, Church GM, Chisholm SW (2007) Genome-wide expression dynamics of a marine virus and host reveal features of co-evolution. Nature 449(7158):83-86.