Prof. Dr. Kai Stühler

Research focus

The group of Kai Stühler is interested in the elucidation of spatiotemporal organization of complex biological systems by proteomic analysis in the field of cell differentiation, regeneration and aging. With the combination of protein mass spectrometry and high resolution protein separation proteomics allows to quantify protein abundance and characterize proteins primary structure, posttranslational modification status on a molecular level.

The ten most important publications

  1. Stratmann B, Engelbrecht B, Espelage BC, Klusmeier N, Tiemann J, Gawlowski T, Mattern Y, Eisenacher M, Meyer HE, Rabbani N, Thornalley PJ, Tschoepe D, Poschmann G, Stühler K. (2016) Glyoxalase 1-knockdown in human aortic endothelial cells - effect on the proteome and endothelial function estimates. Sci Rep. 2016 Nov 29;6:37737
  2. Lundquist PK, Mantegazza O, Stefanski A, Stühler K, Weber AP. (2016) Surveying the Oligomeric State of Arabidopsis thaliana Chloroplasts. Mol Plant. 2016 Oct 26. pii: S1674-2052(16)30236-2.
  3. Correa-Galvis V, Poschmann G, Melzer M, Stühler K, Jahns P. (2016) PsbS interactions involved in the activation of energy dissipation in Arabidopsis. Nat Plants. 2016 Feb 1;2:15225.
  4. Schira J, Falkenberg H, Hendricks M, Waldera-Lupa DM, Kögler G, Meyer HE, Müller HW, Stühler K. (2015) Characterization of Regenerative Phenotype of Unrestricted Somatic Stem Cells (USSC) from Human Umbilical Cord Blood (hUCB) by Functional Secretome Analysis. Mol Cell Proteomics. 2015 Oct;14(10):2630-43
  5. Waldera Lupa DM, Kalfalah F, Safferling K, Boukamp P, Poschmann G, Volpi E, Götz-Rösch C, Bernerd F, Haag L, Huebenthal U, Fritsche E, Boege F, Grabe N, Tigges J, Stühler K, Krutmann J (2015) Characterization of Skin Aging-Associated Secreted Proteins (SAASP) Produced by Dermal Fibroblasts Isolated from Intrinsically Aged Human Skin. J Invest Dermatol. 2015 Aug;135(8):1954-68.
  6. Poschmann G, Grzendowski M, Stefanski A, Bruns E, Meyer HE, Stühler K. (2015) Redox proteomics reveal stress responsive proteins linking peroxiredoxin-1 status in glioma to chemosensitivity and oxidative stress. Biochim Biophys Acta. 2015 Jun;1854(6):624-31.
  7. Aldous SH, Weise SE, Sharkey TD, Waldera-Lupa DM, Stühler K, Mallmann J, Groth G, Gowik U, Westhoff P, Arsova B. (2014) Evolution of the Phosphoenolpyruvate Carboxylase Protein Kinase Family in C3 and C4 Flaveria spp. Plant Physiol. 2014 Jul;165(3):1076-1091.
  8. Tigges J, Krutmann J, Fritsche E, Haendeler J, Schaal H, Fischer JW, Kalfalah F, Reinke H, Reifenberger G, Stühler K, Ventura N, Gundermann S, Boukamp P, Boege F. (2014) The hallmarks of fibroblast ageing. Mech Ageing Dev. 2014 Jun;138:26-44.
  9. Waldera-Lupa DM, Kalfalah F, Florea AM, Sass S, Kruse F, Rieder V, Tigges J, Fritsche E, Krutmann J, Busch H, Boerries M, Meyer HE, Boege F, Theis F, Reifenberger G, Stühler K. (2014) Proteome-wide analysis reveals an age-associated cellular phenotype of in situ aged human fibroblasts. Aging (Albany NY). 2014 Oct;6(10):856-78.
  10. Poschmann G, Seyfarth K, Besong Agbo D, Klafki HW, Rozman J, Wurst W, Wiltfang J, Meyer HE, Klingenspor M, Stühler K. (2014) High-fat diet induced isoform changes of the Parkinson's disease protein DJ-1.J Proteome Res. 2014 May 2;13(5):2339-51.
Prof. Dr. Kai Stühler
CEPLAS Kai Stühler

kai.stuehler[at]hhu.de

 +49 211 81-13036

Centre for Biological and Medical Research (BMFZ)
Heinrich Heine University Düsseldorf

Universitätsstraße 1

40225 Düsseldorf

molecular-proteomics-laboratory.de

Heinrich Heine University
University of Cologne
Max Planck Institute for Plant Breeding Research
Forschungszentrum Jülich