Prof. Dr. Andreas P.M. Weber

Research focus

Our research is addressing specific aspects of plant cell function through a combination of evolutionary and comparative transcriptomics, systems biology, biochemistry, and plant physiology. In particular, we are aiming at a systems-level understanding of photorespiration and C4 photosynthesis and the regulatory principles that govern plant metabolic networks. In addition to addressing fundamental questions in plant cell biology and metabolism, our work provides a scientific basis and blueprints for synthetic biology approaches to maximize photosynthetic productivity.

The ten most important publications

  1. Schuler ML, Mantegazza O, Weber AP (2016) Engineering C4 photosynthesis into C3 chassis in the synthetic biology age. Plant J 87(1):51-65.
  2. Ort DR, Merchant SS, Alric J, Barkan A, Blankenship RE, Bock R, Croce R, Hanson MR, Hibberd JM, Long SP, Moore TA, Moroney J, Niyogi KK, Parry MA, Peralta-Yahya PP, Prince RC, Redding KE, Spalding MH, van Wijk KJ, Vermaas WF, von Caemmerer S, Weber AP, Yeates TO, Yuan JS, Zhu XG (2015) Redesigning photosynthesis to sustainably meet global food and bioenergy demand. Proc Natl Acad Sci U S A 112(28):8529-8536.
  3. Mallmann J, Heckmann D, Bräutigam A, Lercher MJ, Weber AP, Westhoff P, Gowik U (2014) The role of photorespiration during the evolution of C4 photosynthesis in the genus Flaveria. eLife 3:e02478.
  4. Külahoglu C, Denton AK, Sommer M, Mass J, Schliesky S, Wrobel TJ, Berckmans B, Gongora-Castillo E, Buell CR, Simon R, De Veylder L, Bräutigam A, Weber AP (2014) Comparative transcriptome atlases reveal altered gene expression modules between two Cleomaceae C3 and C4 plant species. The Plant cell 26(8):3243-3260.
  5. Schönknecht G, Chen WH, Ternes CM, Barbier GG, Shrestha RP, Stanke M, Bräutigam A, Baker BJ, Banfield JF, Garavito RM, Carr K, Wilkerson C, Rensing SA, Gagneul D, Dickenson NE, Oesterhelt C, Lercher MJ, Weber AP (2013) Gene transfer from bacteria and archaea facilitated evolution of an extremophilic eukaryote. Science 339(6124):1207-1210.
  6. Pick TR, Bräutigam A, Schulz MA, Obata T, Fernie AR, Weber AP (2013) PLGG1, a plastidic glycolate glycerate transporter, is required for photorespiration and defines a unique class of metabolite transporters. Proc Natl Acad Sci U S A 110(8):3185-3190.
  7. Heckmann D, Schulze S, Denton A, Gowik U, Westhoff P, Weber AP, Lercher MJ (2013) Predicting C4 photosynthesis evolution: modular, individually adaptive steps on a Mount Fuji fitness landscape. Cell 153(7):1579-1588.
  8. Eisenhut M, Planchais S, Cabassa C, Guivarc'h A, Justin AM, Taconnat L, Renou JP, Linka M, Gagneul D, Timm S, Bauwe H, Carol P, Weber AP (2013) Arabidopsis A BOUT DE SOUFFLE is a putative mitochondrial transporter involved in photorespiratory metabolism and is required for meristem growth at ambient CO(2) levels. Plant J 73(5):836-849.
  9. Pick TR, Brautigam A, Schlüter U, Denton AK, Colmsee C, Scholz U, Fahnenstich H, Pieruschka R, Rascher U, Sonnewald U, Weber AP (2011) Systems analysis of a maize leaf developmental gradient redefines the current C4 model and provides candidates for regulation. The Plant cell 23(12):4208-4220.
  10. Furumoto T, Yamaguchi T, Ohshima-Ichie Y, Nakamura M, Tsuchida-Iwata Y, Shimamura M, Ohnishi J, Hata S, Gowik U, Westhoff P, Bräutigam A, Weber AP, Izui K (2011) A plastidial sodium-dependent pyruvate transporter. Nature 476(7361):472-475.
Prof. Dr. Andreas P.M. Weber
CEPLAS Andreas Weber

aweber[at]hhu.de

 +49 211 81-12347

Institute of Plant Biochemistry
Heinrich Heine University Düsseldorf

Universitätsstraße 1

40225 Düsseldorf

www.plant-biochemistry.hhu.de

Heinrich Heine University
University of Cologne
Max Planck Institute for Plant Breeding Research
Forschungszentrum Jülich