Prof. Dr. Karl Köhrer

Research focus

Systematic and global analyses of genomes and transcriptomes are needed to identify and study the genetic basis of complex regulatory pathways. Therefore, we are providing genome-wide DNA and RNA analyses using microarray and next generation DNA sequencing technologies to deliver the basis for a comprehensive understanding of complex traits.

The ten most important publications

  1. Mykicki N, Herrmann AM, Schwab N, Deenen R, Sparwasser T, Limmer A, Wachsmuth L, Klotz L, Köhrer K, Faber C, Wiendl H, Luger TA, Meuth SG, Loser K (2016). Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease. Sci. Transl. Med. 8 (362): pp. 362ra146 (DOI: 10.1126/scitranslmed.aaf8732).
  2. Molojavyi A, Lindecke A, Raupach A, Moellendorf S, Köhrer K, Gödecke A (2010). Myoglobin-deficient mice activate a distinct cardiac gene expression program in response to isoproterenol-induced hypertrophy. Physiological Genomics 41(2): 137-145.
  3. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blöcker H Heubner D, Hoerlein A, Michel G, Wedler H, Köhrer K, Ottenwälder B, Poustka A, Wiemann S, Schupp I (2007) The full-ORF clone resource of the German cDNA Consortium. BMC Genomics 8: 399.
  4. Beyer A, Scheuring S, Müller S, Mincheva A, Lichter P, Köhrer K (2003). Comparative sequence and expression analyses of four mammalian VPS4 genes. Gene 305(1): 47-59.
  5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blöcker H, Bauersachs S, Blum H Lauber J, Düsterhoft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. Genome Research 11(3): 422-435.
  6. Scheuring S, Bodor O, Röhricht RA, Müller S, Beyer A, Köhrer K (1999). Cloning, characterisation, and functional expression of the Mus musculus SKD1 gene in yeast demonstrates that the mouse SKD1 and the yeast VPS4 genes are orthologues and involved in intracellular protein trafficking. Gene 234(1): 149-159.
  7. Köhrer K, Emr SD (1993). The yeast VPS17 gene encodes a membrane-associated protein required for the sorting of soluble vacuolar hydrolases. The Journal of Biological Chemistry 268(1): 559-569.
  8. Köhrer K, Domdey H (1991). Preparation of high molecular weight RNA. Methods in Enzymology 194: 398-405.
  9. Köhrer K, Vogel K, Domdey H (1990). A yeast tRNA precursor containing a pre-mRNA intron is spliced via the pre-mRNA splicing mechanism. The EMBO Journal 9(3): 705-709.
  10. Köhrer K, Kutchan TM, Domdey H (1989). Specific oligodeoxynucleotide probes obtained through RNA sequencing. DNA 8(2): 143-147.
Prof. Dr. Karl Köhrer
CEPLAS Karl Köhrer

koehrer[at]hhu.de

 +49 211 81-13165

Centre for Biological and Medical Research (BMFZ)
Heinrich Heine University Düsseldorf

Moorenstraße 5

40225 Düsseldorf

www.bmfz-gtl.de

Heinrich Heine University
University of Cologne
Max Planck Institute for Plant Breeding Research
Forschungszentrum Jülich