Prof. Dr. Ilka Maria Axmann

Smart, automated and dynamic control of synthetic metabolic pathways in microorganisms is aimed using synthetic RNA-devices and RNA-based metabolite-sensors. Particular focus is placed on the engineering of cyanobacteria as a future host for sustainable biotechnology.

1. Guerreiro AC, Penning R, Raaijmakers LM, Axman IM, Heck AJ, Altelaar AF (2016) Monitoring light/dark association dynamics of multi-protein complexes in cyanobacteria using size exclusion chromatography-based proteomics. J Proteomics 142:33-44.
2. Amos M, Axmann IM, Blüthgen N, de la Cruz F, Jaramillo A, Rodriguez-Paton A, Simmel F (2015) Bacterial computing with engineered populations. Philos Trans A Math Phys Eng Sci 373(2046).
3. Snijder J, Burnley RJ, Wiegard A, Melquiond AS, Bonvin AM, Axmann IM, Heck AJ (2014) Insight into cyanobacterial circadian timing from structural details of the KaiB-KaiC interaction. Proc Natl Acad Sci U S A 111(4):1379-1384.
4. Beck C, Hertel S, Rediger A, Lehmann R, Wiegard A, Kölsch A, Heilmann B, Georg J, Hess WR, Axmann IM (2014) Daily expression pattern of protein-encoding genes and small noncoding RNAs in synechocystis sp. strain PCC 6803. Appl Environ Microbiol 80(17):5195-5206.
5. Lehmann R, Machné R, Georg J, Benary M, Axmann I, Steuer R (2013) How cyanobacteria pose new problems to old methods: challenges in microarray time series analysis. BMC Bioinformatics 14:133.
6. Hertel S, Brettschneider C, Axmann IM (2013) Revealing a two-loop transcriptional feedback mechanism in the cyanobacterial circadian clock. PLoS Comput Biol 9(3):e1002966.
7. Beck C, Knoop H, Axmann IM, Steuer R (2012) The diversity of cyanobacterial metabolism: genome analysis of multiple phototrophic microorganisms. BMC genomics 13:56.
8. Brettschneider C, Rose RJ, Hertel S, Axmann IM, Heck AJ, Kollmann M (2010) A sequestration feedback determines dynamics and temperature entrainment of the KaiABC circadian clock. Mol Syst Biol 6:389.
9. Axmann IM, Dühring U, Seeliger L, Arnold A, Vanselow JT, Kramer A, Wilde A (2009) Biochemical evidence for a timing mechanism in prochlorococcus. J Bacteriol 191(17):5342-5347.
10. Lindell D, Jaffe JD, Coleman ML, Futschik ME, Axmann IM, Rector T, Kettler G, Sullivan MB, Steen R, Hess WR, Church GM, Chisholm SW (2007) Genome-wide expression dynamics of a marine virus and host reveal features of co-evolution. Nature 449(7158):83-86.