Dr. Alisandra Denton

Research Focus

My research focusses on leveraging the upcomming and powerful Deep Learning tool to better understand and predict the functions of biological sequences. In particular we’ve developed a top-performing prototype Eukaryotic gene caller. Once finished, this will allow for easier, faster, and more consistent generation of structural gene annotations, facilitating downstream analyses from cloning to comparative genomics.

 

The five most important publications

  • Heckmann, D., Schulze, S., Denton, A., Gowik, U., Westhoff, P., Weber, A. P., & Lercher, M. J. (2013). Predicting C4 photosynthesis evolution: modular, individually adaptive steps on a Mount Fuji fitness landscape. Cell, 153(7), 1579-1588
  • Vogel, A., Schwacke, R., Denton, A. K., Usadel, B., Hollmann, J., Fischer, K., ... & Mayer, K. F. (2018). Footprints of parasitism in the genome of the parasitic flowering plant Cuscuta campestris. Nature communications, 9(1), 1-11
  • Schmidt, M. H. W., Vogel, A., Denton, A. K., Istace, B., Wormit, A., van de Geest, H., ... & Schurr, U. (2017). De novo assembly of a new Solanum pennellii accession using nanopore sequencing. The Plant Cell, 29(10), 2336-2348
  • Denton, A. K., Maß, J., Külahoglu, C., Lercher, M. J., Bräutigam, A., & Weber, A. P. (2017). Freeze-quenched maize mesophyll and bundle sheath separation uncovers bias in previous tissue-specific RNA-Seq data. Journal of experimental botany, 68(2), 147-160
  • Külahoglu, C., Denton, A. K., Sommer, M., Maß, J., Schliesky, S., Wrobel, T. J., ... & De Veylder, L. (2014). Comparative transcriptome atlases reveal altered gene expression modules between two Cleomaceae C3 and C4 plant species. The Plant Cell, 26(8), 3243-3260
Dr. Alisandra Denton

alisandra.denton[at]hhu.de

+49 211 8115477

Institute of Plant Biochemistry
Heinrich Heine University Düsseldorf

Universitätsstr. 1

40225 Düsseldorf

http://www.plant-biochemistry.hhu.de
Heinrich Heine University
University of Cologne
Max Planck Institute for Plant Breeding Research
Forschungszentrum Jülich